Colorado State University Researchers Develop New Method to Study DNA Replication
Researchers at Colorado State University have discovered a new way to study DNA replication using genetically modified yeast. This method offers a clearer understanding of cell cycle arrest, which is crucial for cancer treatment and genetic research. The study, led by Assistant Professor Grant Schauer, was published in the Proceedings of the National Academy of Sciences.
Understanding DNA Replication
The research focuses on hydroxyurea, a drug used in cancer treatment and research to halt cell development. This helps scientists study how cells copy DNA before dividing. However, hydroxyurea was found to create harmful reactions in cells, affecting the study of DNA replication.
New Approach with Genetically Modified Yeast
To overcome these issues, the team developed a system using genetically engineered yeast cells called RNR-deg. This system is less toxic and quickly reversible compared to hydroxyurea. The new method could change how researchers study cell arrest.
Future Research
The team plans to transfer this technique from yeast cells to human cells. Schauer believes this new method is a superior alternative to hydroxyurea, as it avoids negative effects that have hindered understanding. The research was funded by the National Institutes of Health, with contributions from undergraduate researchers like Hannah Reitman.
Doubts Revealed
Colorado State University -: Colorado State University is a big school in the United States where people go to learn and do research. It’s like a college where smart people study different subjects.
DNA Replication -: DNA replication is the process by which a cell makes a copy of its DNA. It’s like making a duplicate of a book so that both copies have the same information.
Genetically Modified Yeast -: Genetically modified yeast are tiny living things that have been changed in a lab to have special traits. Scientists use them to study how cells work.
Cell Cycle Arrest -: Cell cycle arrest is when a cell stops dividing. This is important in cancer treatment because it can help stop cancer cells from growing.
Hydroxyurea -: Hydroxyurea is a medicine used in research and sometimes in treating diseases. It can cause some bad reactions in cells, which scientists want to understand better.
RNR-deg Yeast -: RNR-deg yeast is a special type of yeast used in research that is less harmful to cells. It helps scientists study DNA without causing too much damage.
Reversible -: Reversible means something can be changed back to how it was before. In this context, it means the effects on the cells can be undone.
