Columbia Researchers Develop Bacterial Vaccine to Fight Cancer
Scientists at Columbia University have created a new type of cancer vaccine using probiotic bacteria. This innovative approach trains the immune system to target and destroy cancer cells, offering hope for personalized cancer treatments.
How It Works
The vaccine uses genetically modified E. coli bacteria to deliver protein targets, known as neoantigens, specific to a patient’s cancer. These neoantigens help the immune system recognize and attack cancer cells while leaving healthy cells unharmed.
Success in Animal Models
In tests on mice with advanced colorectal cancer and melanoma, the bacterial vaccine successfully reduced or eliminated tumors. The vaccine was more effective than previous peptide-based cancer vaccines.
Personalized Treatment
Each vaccine is tailored to the individual’s cancer, using bioinformatics to identify unique neoantigens. This customization aims to prevent cancer recurrence and improve patient outcomes.
Future Prospects
Researchers are optimistic about testing this therapy in humans. The bacterial vaccine could offer a more targeted and effective treatment option, potentially overcoming challenges faced by earlier cancer vaccines.
Doubts Revealed
Columbia University -: Columbia University is a famous school in the United States where people study and do research. It’s like a big college where smart people work on important projects.
Probiotic bacteria -: Probiotic bacteria are tiny living things that are good for our health. They are often found in foods like yogurt and help keep our stomachs healthy.
Cancer vaccine -: A cancer vaccine is a special medicine that helps the body’s defense system fight cancer. It teaches the body to find and destroy cancer cells.
Immune system -: The immune system is like a superhero team inside our body that fights off bad germs and keeps us healthy. It helps protect us from getting sick.
Neoantigens -: Neoantigens are special proteins found on cancer cells that are different from normal cells. They help the immune system recognize and attack cancer cells.
Mouse models -: Mouse models are experiments done on mice to study how new treatments might work in humans. Scientists use mice because they can learn a lot about diseases and medicines from them.
Personalized cancer treatment -: Personalized cancer treatment means creating a special plan to treat cancer that is just right for each person. It’s like having a custom-made medicine that works best for you.