Colorado State University Researchers Develop New Method to Study DNA Replication
Researchers at Colorado State University have discovered a new way to study DNA replication using genetically modified yeast. This method offers a clearer understanding of cell cycle arrest, which is crucial for cancer treatment and genetic research. The study, led by Assistant Professor Grant Schauer, was published in the Proceedings of the National Academy of Sciences.
Understanding DNA Replication
The research focuses on hydroxyurea, a drug used in cancer treatment and research to halt cell development. This helps scientists study how cells copy DNA before they divide. However, the drug was found to create harmful reactions in cells, affecting the study of DNA replication.
New Approach with Genetically Modified Yeast
To overcome these issues, the team developed a system using genetically engineered yeast cells called RNR-deg. This system is less toxic and quickly reversible compared to hydroxyurea. The new method could change how researchers study cell arrest.
Future Research
The team plans to transfer this technique from yeast cells to human cells. Schauer believes this new method is a superior alternative to hydroxyurea, as it avoids the negative effects that have hindered understanding in the past.
Contributions and Funding
The research was funded by the National Institutes of Health, with contributions from undergraduate researchers, including Hannah Reitman, who gained valuable experience through the project.
Doubts Revealed
Colorado State University -: Colorado State University is a big school in the United States where people go to learn and do research. It’s like a college where smart people study different subjects.
DNA Replication -: DNA replication is the process by which a cell makes a copy of its DNA. It’s like making a duplicate of a recipe so you can have two copies.
Genetically Modified Yeast -: Genetically modified yeast is a type of yeast that scientists have changed to help them study things. It’s like changing a toy to see how it works better.
Hydroxyurea -: Hydroxyurea is a medicine used to treat some types of cancer. It helps stop cancer cells from growing, but it can also cause some bad reactions in the body.
RNR-deg -: RNR-deg is a new system developed by scientists using yeast to study DNA replication. It’s a safer way to learn about how cells copy their DNA without causing harm.
Cell Cycle Arrest -: Cell cycle arrest is when a cell stops dividing and growing. It’s like pressing the pause button on a video to stop it from playing.
